I don't think losing this game would be particularly damaging. I'm not saying I don't want to win it, I do, I never want to lose, I just don't think losing a LC match where we play a rotated side (I presume) is ever going to be particularly impactful.
I do think, though, that another league match without scoring at the weekend would really start to weigh heavy.
I am not saying it would put the manager at risk, I am saying it would really start to weigh heavy around the necks of the players, and the atmosphere around the club would be fast becoming rotten.