The risk with starting a strong team is that we don't get it done early, and everyone ends up playing way longer than planned. This happened at least once in Europe last season. The risk with starting a "weak" team is that we don't get it done at all.
On paper we should be able to make a lot of changes and still win comfortably, but on paper we shouldn't have been losing 0-2 to Everton, and we shouldn't have been losing 0-1 to Wolves for 70 minutes.
I think Maatsen, Nedeljkovic/Bogarde, Bailey, Barkley, and Duran should start. Assuming we're home and hosed by the hour mark, some of the other starters can be subbed off.