4-4-2 won't work with our players. The only occasions I can see it working (unless you have Yaya Toure) is when one of the "two" can supplement the midfield e.g. Rooney and Suarez. The 442 blueprint for me is the early Arsene Wenger teams. Three solid midfielder and one flying winger and a Bergkamp who can drop deep to stop the lines of midfield and attack becoming too separated. Arsene first had Parlour and Overmars in the wide positions and then MK II, Llundberg and Pires.
We just don't have those players, and I'm talking type of players, not quality.